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Kirken, Robert
One or more keywords matched the following items that are connected to Kirken, Robert
Item TypeName
Academic Article Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
Academic Article Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways.
Academic Article Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosuppression.
Academic Article JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
Academic Article Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
Academic Article Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
Academic Article Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
Academic Article Activation of receptor-associated tyrosine kinase JAK2 by prolactin.
Academic Article Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.
Academic Article Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha.
Academic Article Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.
Academic Article Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
Academic Article Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
Academic Article Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.
Academic Article Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
Academic Article Targeting Jak3 for immune suppression and allograft acceptance.
Academic Article PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
Academic Article Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
Academic Article The role of IL-2 in allograft rejection--a lesson learned from experimental work.
Academic Article Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
Academic Article Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
Academic Article The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.
Academic Article Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells.
Academic Article JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization.
Academic Article Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
Academic Article Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors.
Academic Article Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
Academic Article Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.
Academic Article STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
Academic Article Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
Academic Article Nitric oxide and thiol redox regulation of Janus kinase activity.
Concept Janus Kinase 1
Concept Janus Kinase 2
Concept Janus Kinase 3
Academic Article JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling.
Academic Article JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
Academic Article Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies.
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